Could Ketamine Therapy Transform Mental Health Care

Could Ketamine Therapy Transform Mental Health Care?

Written by: Karalynne Call

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Time to read 3 min

In a recent episode of the Just Ingredients podcast, I sat down with Dr. Nathan Gilmore, a board-certified physician and Chief Medical Director of Anew Therapy, to discuss an emerging and often misunderstood approach to mental health: ketamine therapy.


With over a decade of medical experience, Dr. Gilmore has turned his focus to using ketamine to help treat depression, anxiety, PTSD, and other severe mental health conditions. We covered how ketamine works, what a treatment session is like, and how this method offers new hope to those dealing with treatment-resistant mental health challenges.


If you or someone close to you is navigating severe depression, anxiety, or PTSD, ketamine therapy might offer a life-changing alternative. Here, we share key insights from the episode to shed light on how ketamine could transform the path to mental wellness.


Listen to the full episode:


What is Ketamine, and How Did It Become a Mental Health Treatment?

Originally developed as an anesthetic, ketamine was used in the Vietnam War for pain management. Physicians observed that patients receiving ketamine sometimes experienced mood improvements following surgery, sparking interest in researching ketamine’s potential impact on mental health.


Key Points on Ketamine’s History:


  • History: Initially used as an anesthetic, especially in emergency settings.
  • Research: Interest grew after patients showed unexpected mood improvements post-surgery.
  • Current Understanding: Recognized as a potential treatment for individuals with mental health conditions that haven't responded to traditional methods.

Dr. Gilmore shared that ketamine has shown an impact on individuals experiencing treatment-resistant depression, with studies suggesting a possible reduction in symptoms after treatments.

How Does Ketamine Work?

Dr. Gilmore explained that ketamine operates through the brain’s glutamate system, which plays a role in mood regulation. By blocking certain receptors, ketamine influences neurotransmitter pathways, potentially assisting the brain in moving away from negative thought cycles, depression, and anxiety.


Key Mechanisms of Ketamine:


  • Can interact with the glutamate system, crucial for mood.
  • Can influence neurotransmitter pathways, aiding communication in the brain.
  • Can support neuroplasticity, helping the brain form new connections.

When someone is in a cycle of depression or anxiety, it’s as if the brain only knows one route—the one leading to negative thoughts. Ketamine can help redirect that flow, allowing for the formation of new pathways. This process, known as neuroplasticity, enables the brain to adapt and create changes.

What to Expect During a Ketamine Treatment Session

A ketamine treatment session involves creating a calm, supportive setting where patients can set personal intentions. Typically, ketamine is administered through an injection, inducing a dissociative, dreamlike state that allows patients to distance themselves from habitual thoughts and stress.


Key Aspects of Ketamine Sessions:


  • Importance of a calming environment for effective treatment.
  • Administered through injection, inducing a unique mental experience.
  • Some may see improvement after a single session, while others benefit from multiple treatments.

Dr. Gilmore notes, “80% of patients have the severity of their symptoms cut in half from ketamine therapy. It changes people’s lives.”

Understanding Common Misconceptions About Ketamine

Despite its clinical potential, ketamine is sometimes misunderstood due to associations with recreational use. In a clinical setting, ketamine is administered responsibly, similarly to other medical treatments.


Key Misconceptions:


  • Often stigmatized due to recreational associations.
  • Safe when used under proper medical guidance.
  • Does not change a person’s personality; instead, it can alleviate overwhelming symptoms.

Dr. Gilmore likened it to morphine: both substances require careful management but play essential roles in therapeutic contexts.

Is Ketamine Therapy Right for You?

For individuals facing mental health conditions that have not responded to traditional treatments, ketamine might offer an alternative path. Research indicates that ketamine can impact treatment-resistant conditions, and Dr. Gilmore has observed improvements in many of his patients.


Key Considerations:


  • Alternative therapy option for treatment-resistant conditions.
  • Best used alongside lifestyle changes for optimal results.
  • Not a standalone solution; should be part of a broader mental wellness approach.

However, ketamine is not a standalone solution; it is best used within a comprehensive approach to mental wellness that includes lifestyle practices like balanced nutrition, physical activity, and therapy.


Navigating mental health challenges can be an incredibly isolating experience, but it’s essential to remember that you’re not alone. Many individuals face similar struggles, and there is a community of support available. It takes immense strength to confront these challenges and seek help, whether through therapy, medication, or alternative approaches like ketamine therapy. Each step you take toward healing is a testament to your resilience and a crucial part of your journey. Know that there is hope, and brighter days are possible.